Some protic ionic liquids (PILs) were synthesized by the direct neutralization reaction of N-methylimidazole and 4-N,N-dimethylaminopyridine as nitrogen-containing heterocyclic organic bases with acetic acid and trifluoroacetic acid. The relative acidity of the prepared ionic liquids was evaluated by Hammet's acidity function using UV-Vis spectroscopy. The catalytic effects of the obtained ionic liquids were investigated in the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thione derivatives through Biginelli reaction. AmongN-methylimidazolium acetate [MImH][OAc], N-methylimidazolium trifluoroacetate [MImH][CF3CO2], 4-N,N-dimethylaminopyridinium acetate [DMAPH][OAc] and 4-N,N-dimethylaminopyridinium trifluoroacetate [DMAPH][CF3CO2], [MImH][OAc] provided the best results. Using 5 mol% of [MImH][OAc] as a catalyst, 3,4-dihydropyrimidin-2-(1H)-ones and thione derivatives were obtained in high to excellent yields at 100 ºC during 15-50 min.
Ramezani Gomari, F., Farahi, S., & Arvinnezhad, H. (2021). Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones and Thione Derivatives Through the Biginelli Protocol Using N-Methylimidazolium Acetate. Iranian Journal of Chemistry and Chemical Engineering, 40(3), 888-897. doi: 10.30492/ijcce.2020.38166
MLA
Fatemeh Ramezani Gomari; Soghra Farahi; Hamid Arvinnezhad. "Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones and Thione Derivatives Through the Biginelli Protocol Using N-Methylimidazolium Acetate". Iranian Journal of Chemistry and Chemical Engineering, 40, 3, 2021, 888-897. doi: 10.30492/ijcce.2020.38166
HARVARD
Ramezani Gomari, F., Farahi, S., Arvinnezhad, H. (2021). 'Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones and Thione Derivatives Through the Biginelli Protocol Using N-Methylimidazolium Acetate', Iranian Journal of Chemistry and Chemical Engineering, 40(3), pp. 888-897. doi: 10.30492/ijcce.2020.38166
VANCOUVER
Ramezani Gomari, F., Farahi, S., Arvinnezhad, H. Facile and Rapid Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones and Thione Derivatives Through the Biginelli Protocol Using N-Methylimidazolium Acetate. Iranian Journal of Chemistry and Chemical Engineering, 2021; 40(3): 888-897. doi: 10.30492/ijcce.2020.38166