Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid

Vijayarathinam, M.; Kannan, A.; Nepolraj, A.; Akilan, P.; Chanrasekaran, V.; Gunasekaran, T.

doi:10.30492/ijcce.2022.559177.5475

Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: 3-Indoloylquinoline Alkaloid

Document Type : Research Article

Authors

¹ Government Arts College (Autonomous), Salem-7, TN, INDIA

² Department of Chemistry, Government Arts College (Autonomous), Salem-7, TN, INDIA

³ Department of Chemistry, Annai College of Arts and Science, Kovilacheri, Kumbakonam, INDIA

10.30492/ijcce.2022.559177.5475

Abstract

An exclusive approach towards the synthesis of indoylquinoline alkaloids has been illustrated, the present article describes the synthesis, in Platelet-derived growth factor receptor and silico molecular docking studies of a new compound 3-indolylquinoline-2,4-diol 4. The synthesis of 4 is initiated by a new, efficient, and solvent-free via a thermal Claisen condensation. The structures of the compounds are established using both spectral and analytical data. An in-silico PASS, Swiss ADME-assisted docking approach is found to be suitable for deriving and synthesizing effective receptor tyrosine kinase agents. Claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents. Structures of the newly synthesized compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR, and HRMS (FTMS+PESI) analyses.

Keywords