Preparation, In-Vitro Evaluation, and Delivery of Colchicine via Polyacrylamide Hydrogel

Li, Xiaoxia; Li, Yangyang; Wang, Min; Meng, Fanjun; Huang, Jinling; Yu, Rui; Wang, Yangying; Liu, Huan Huan

doi:10.30492/ijcce.2021.533974.4830

Preparation, In-Vitro Evaluation, and Delivery of Colchicine via Polyacrylamide Hydrogel

Document Type : Research Article

Authors

¹ The College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, P.R. CHINA

² Department of General Surgery, the Fourth Affiliated Hospital of Anhui Medical University, No. 100 Huaihai Road, Hefei 230012, Anhui, P.R. CHINA

10.30492/ijcce.2021.533974.4830

Abstract

Hydrogels have excellent biocompatibility and are widely used in biomedical applications. However, it is still a challenge to build a hydrogel with outstanding mechanical properties and multiple functions. In this study, a polyacrylamide (PAM) hydrogel with a uniform network structure was achieved through an UltraViolet (UV)-responsive organic crosslinking agent and a higher mechanical strength PAM-Ag⁺hydrogel was designed through the introduction of silver ion by metal coordination interaction. Various contents of N'N-bis(acryloyl)cysteamine (BACA) as cross-linker, acrylamide (AM) as a monomer, and Irgacure 2959 as initiator were investigated to have an optimal combination of high strength. Thus, the PAM-Ag⁺ hydrogel exhibited excellent adhesive behavior that could be fixed to the human forearm and any part of the skin, such as the finger and elbow joint. In addition, the properties and biocompatibility evaluations of the tough hydrogel in medical wound dressing were investigated. Meanwhile, these results showed that PAM-Ag⁺ hydrogels possess high stretchable (2600%) and mechanical robust (2.55 MPa) properties. Excitingly, the release of colchicine (Col) of more than 95% in 48 h demonstrated the hydrogel's high potential in medical dressing and drug release applications by virtue of the excellent moisture retention, permeability, water tightness, swelling ratio, and biocompatibility.

Keywords

Main Subjects

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