Analgesic, antipyretic, and antispasmodic activities of solvent fractions derived from Chenopodium ficifolium on albino mice

Articles in Press

Document Type : Research Article

Authors

1 Department of Pediatrics, Shandong Provincial Third Hospital, Shandong University, No.11 Wuyingshan Middle Road, Tianqiao District, Jinan, Shandong, 250031, China

2 Department of Botany, Abdul Wali Khan University Mardan, 23200, Khyber Pakhtunkhwa, Pakistan.

10.30492/ijcce.2024.2020060.6386

Abstract

Albino mice, hot plat-induced spasm, charcoal-induced spasm, and brewer yeast-induced pyrexia were used to assess the analgesic, anti-spasmodic, and antipyretic activities. The experimental groups received doses of 100 and 200 mg/kg of chloroform, n-hexane, ethyl acetate, and aqueous fractions. The n-hexane fraction at a dosage of 200 mg/kg notably prolonged the reaction time (P<0.01) and mitigated paw edema only at the 200 mg/kg level across all models. Significant suppression of rectal temperature was noted with a higher dosage (200 mg/kg) of chloroform friction. Analgesic activity was prominently exhibited by the ethyl acetate fraction, yielding results on par with the established standards. These findings underscore the promise of these fractions in mitigating pain-associated reactions, Brewer's yeast-induced hyperthermia, and charcoal-induced spasms. Enhanced efficacy was evident at dosages of 100 mg/kg and 200 mg/kg of the organic fraction obtained from Chenopodium ficifolium, particularly in the management of fever, pain, and spasmodic conditions.

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Iranian Journal of Chemistry and Chemical Engineering

Articles in Press, Accepted Manuscript
Available Online from 05 May 2024

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